Simmonds' Disease
نویسنده
چکیده
In 1907 Paulesco demonstrated that removal of that pituitary gland caused weakness, loss of weight and death. In 1914 Simmonds reported the first case of the disease called after his name. A woman aged 38 years, after recovering from puerperal sepsis, developed amenorrhcea, increasing weakness, progressive loss of weight, anaemia, and premature senility. He put it down to atrophic degeneration of the anterior pituitary, due to septic emboli. Adequate reviews and compilations of Simmonds' disease have appeared in the medical literature during recent years, notably by Silver (1933), Calder (1932) and Graubner (1925). Farber (1940) reported a case in which he found post mortem marked microsplanchnia of all organs, and a pituitary stalk tumour (cystic epithelioma) which was evidently causing pressure atrophy of the anterior pituitary. Though previous reports were mainly based on post-mortem diagnosis, during recent years cases have been reported which successfully responded to replacement therapy with anterior pituitary extract. Dunn (1936) and Moehlig (1936) have reported cases of cure effected by anterior pituitary hormone therapy. Bergmann (1934) described
منابع مشابه
Management of Hereditary Breast Cancer
D.M. Eccles, P. Simmonds, J. Goddard, M. Coultas, F. Lalloo, G. Evans and N. Haites in collaboration with the European Familial Breast Cancer Collaborative Group Department of Clinical Genetics, Princess Ann Hospital, Coxford Road, Southampton, UK Medical Oncology, Royal South Hants Hospital, Southampton, UK Medical Statistics and Computing, Southampton General Hospital, Southampton, UK Clinica...
متن کاملNitrogen Retention, Creatinuria, and Other Effects of the Treatment of Simmonds' Disease with Methyl Testosterone.
One of the immediate effects of hypophysectomy is a loss of nitrogen (1) and a corresponding loss in weight (2). This change is reflected clinically by the so-called cachexia of Simmonds' disease (3). Nitrogen balance is then re-established at a lower level of body weight with lessened food intake. In the experimental animal, adequate replacement therapy is readily obtained with anterior hypoph...
متن کاملLymphadenopathy in coeliac disease.
We present two cases of adult coeliac disease whose major clinical feature was marked lymphadenopathy. One patient also displayed a peripheral lymphocytosis which varied with treatment of the underlying disease.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 77 شماره
صفحات -
تاریخ انتشار 1942